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Posts: 9
Dec 31 11 9:44 AM
fishmoon witrectotom y rote:ft yu, t hi of hathaye this way: the suspensory ligament of the lens separates the vitreou body from the aqueous humor. Suspensory ligament is formed from the hyaloid membrane. Hyaloid membrane forms zonule of Zinn and that contains suspensory ligament of lens. Anterior to the ligament is aqueous humor secreted by the ciliary body. I think the vitreous/saline can diffuse through the ligament into the anterior/posterior chamber, which itself is anterior to the lens. Vitreous cavity is not fully isolated. How do I know that? I know that people who get intermediate uveitis, one of the cardinal symptoms is floaters! Floaters are almost always due to shadows in vitreous (not aqueous because optics dont allow their shadows to form on retina). So this means vitreous is not "isolated" but things can go into it. Look at anatomy of eye here, http://www.oakparkoptomet...ye-care/anatomy-a-vision You can see clearly that ciliary body which produces aqueous is posterior to suspensory ligament as well and is in touch with vitreous. Vitreous itself truly does not have a blood supply, but the retina it closely attaches to has rich blood supply and there is no doubt that chemicals/drugs can diffuse OUT of the blood vessels into the vitreous. My destroyed vitreous is almost certainly the RESULT of accutane that I took. Either due to direct effects on vitreous or indirect effects on retina, accutane has liquified some part of my vitreous, hence my floaters. So I am positive that very small amounts of contraceptive or anti-depressive drugs DO enter the vitreous, vitreous is not a closed system. Another evidence is that after vitrectomy the saline is replaced by the aqueous because some part of clilary body which secrets the aqueous is posterior to the lens as well. How do drugs entering the vitreous change collagen conformation? Easy. Electrostatic charges, changing solubulity product, changing protein confirmation etc etc, so many ways for these drugs to interact with the vitreous proteins and change their confirmation to form precipitates that we see as floaters. Hope this helped.